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| 1. Oxidatively
modified proteins acquire anti-radical capacity |
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This phenomenon - the anti-radical ability of
proteins ARAP - is assessed as a Warning
Signal of the organism, by detecting a possible
under-supply with antioxidants through the determination
of damage to blood plasma proteins. Thus it is
possible to recognize the risk of diseases in
the "pre-preclinical" stage, to control
relevant therapies, to predict disease complications
and hence to reduce healthcare costs and to maintain
quality of life.
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"Norm"
values say nothing...
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A seemingly
healthy lifestyle with maintainance of norm values
of antioxidative components, like vitamins C and
E, is no guarantee for appropriate supply, since
blood levels represent averages and a raised consumption
at critical sites, like the lungs of smokers or
at inflammation spots, cannot be derived.
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...unless
the degree of oxidative damage is taken into account
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| 2.
A system for determination of anti-radical properties |
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To characterize both anti-radical properties of
and oxidative damage to biological objects and
industrial preparations ABCD has developed a complete
system which includes a series of KITs and appropriate
measuring devices.
Medical applications: characterization
of antioxidative homeostasis in human organism
with ARAP and ARAP-PLUS KITs according to the
following components of the anti-radical capacity
of blood plasma:
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| Parameters
determined with the ARAP KIT: |
| ARAP |
the anti-radical ability
of proteins (quantifies the degree of oxidative
modification) |
Parameters determined with the ARAP-PLUS KIT: |
| ACW |
the integral anti-radical
capacity of blood plasma; |
| ACU |
its urate-independent
component; |
| ASC |
the anti-radical capacity
of ascorbic acid |
Derived parameters: |
| UA |
UA = ACW - ACU; the
anti-radical ability of uric acid |
| AO |
AO = ACU - ASC - ARAP;
the anti-radical ability of unidentified substances
(i.e. components of food, pharmaceuticals) |
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Industrial applications: measuring of antioxidants
using ARAP and ARAP-PLUS KITs in pharmaceutics,
cosmetics, food and chemical industry, ecology,
agriculture, forestry etc. for:
• basic research on free radicals/antioxidants
• control of antioxidant parameters under
different environmental conditions
• quality control of technological processes
• investigations on long-term stability
of products
• screening for new antioxidative agents
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