 |
     |
 |
| |
 |
|
|
| |
 |
|
|
| Definition |
|
|
| |
„Normales
Attribut des aeroben Lebens ist die strukturelle
Schädigung einer Vielzahl von Verbindungen
- DNA, Proteinen, Kohlenhydraten, Lipiden - durch
Oxidation. Die oxidative Schädigung durch
reaktive Sauerstoffspezies wird oxidativer Stress
genannt.“ |
|
|
| |
(„A normal
attribute of aerobic life is the structural damage
of a number of compounds - DNA, proteins, carbohydrates,
lipids - by oxidation. The oxidative damage caused
by reactive oxygen species is called oxidative
stress.“) |
|
| |
(Helmut
Sies, 1986) |
|
| |
Oxidative stress is a result of a disturbed "normal"
balance between pro- and antioxidants. Antioxidant
vitamins and a number of enzymes and non-enzymic
substances are integrated in the antioxidant system
of the organism, which maintains the pro/antioxidative
equilibrium ("antioxidative homeostasis")
to protect against oxidative stress.
|
|
|
| Causes and Consequences |
|
|
| |
The human
organism cannot maintain antioxidative homeostasis
without exogenous supply of antioxidants, especially
vitamins C and E.
The need for and dosage of antioxidants contained
in vitamin cocktails, functional food etc. depends
individually on:
(a) genetic predisposition,
(b) health conditions,
(c) habits (smoking, dietary, stress
etc.),
(d) environmental factors (exposure
to UV-radiation, ionising radiation, pollution
etc.)
Over an extended period of time the disturbed
antioxidative homeostasis results in diseases
and contributes to early aging.
|
|
|
|
|
|
|
|
